Lamb C C, Meskell P, Holupka E J
Joint Center for Radiation Therapy, Harvard Medical School, Boston, Massachusetts, USA.
J Endourol. 2000 May;14(4):337-41. doi: 10.1089/end.2000.14.337.
The goal of radioactive seed implantation in prostate cancer is to treat the tumor to the necessary dose while minimizing the dose to adjacent normal structures. The uniform and peripheral loading schemes used in the past have serious limitations. However, with the availability of three-dimensional treatment-planning systems, it has become possible to do custom volume loading based on volumetric ultrasound imaging of the gland. As a result, the dose distributions are more uniform, and the doses to the urethra and rectum are maintained in a safe range.
前列腺癌放射性粒子植入的目标是将肿瘤治疗至所需剂量，同时使邻近正常组织的剂量最小化。过去使用的均匀和周边布源方案存在严重局限性。然而，随着三维治疗计划系统的出现，基于腺体的容积超声成像进行定制化容积布源已成为可能。因此，剂量分布更加均匀，尿道和直肠的剂量也能保持在安全范围内。
