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[肌源性前庭诱发电位用于客观评估中枢作用药物的疗效]

[Myogenic vestibular evoked potentials used to objective estimation of effectiveness of central action drugs].

作者信息

Morawiec-Bajda A, Wasilewski B

出版信息

Otolaryngol Pol. 2000;54(3):327-36.

Abstract

In this paper possibility of employing vestibular evoked myogenic potentials (VEMPs) was evaluated to following efficacy of drug effect in patients with central and peripheral vestibular disorders of various aetiologies. Also influence of antihomotoxic remedies on sacculo-collic reflex function were followed. Treatment concerned 23 ills that is 20 women and 3 men in age from 20 to 68 years, average age being 46,82 years. The studied population included 8 patients were diagnosed to have Meniere's disease, 5 ills suffered from neuronitis vestibularis, 5 patients complained of vertigo of vertebrobasilar arterial insufficiency. 3 patients were diagnosed to have vertigo after head trauma, 1 patient suffered from benign paroxysmal positional vertigo and one's cause of disease was unknown. Patients with tumor of ponto-cerebellaris angle or VIII nerve were excluded. Registration of VEMPs was done in all patients treated before starting and after stopping therapy. After using of Cerebrum comp. improvement of vestibulo-spinal reflex function was affirmed in the form of shorted latencies and higher amplitudes of VEMPs in the most patients. Using sublingually of Vertigoheel distinct greater amplitudes were observed in significant numbers of patients after therapy. Administered of placebo did not essential influence on values of VEMPs parameters.

摘要

本文评估了在前庭诱发肌源性电位(VEMPs)的应用可能性,以跟踪不同病因的中枢性和外周性前庭疾病患者的药物疗效。还跟踪了抗同种毒素药物对球囊 - 颈反射功能的影响。治疗涉及23例患者,即20名女性和3名男性,年龄在20至68岁之间,平均年龄为46.82岁。研究人群包括8例被诊断为梅尼埃病的患者,5例患有前庭神经炎,5例抱怨椎基底动脉供血不足引起的眩晕。3例患者被诊断为头部外伤后眩晕,1例患有良性阵发性位置性眩晕,1例病因不明。排除桥小脑角或第八对脑神经肿瘤患者。在所有接受治疗的患者开始治疗前和停止治疗后进行VEMPs记录。使用脑复康后,大多数患者的前庭脊髓反射功能得到改善,表现为VEMPs潜伏期缩短和波幅升高。舌下使用眩晕停后,大量患者治疗后观察到明显更大的波幅。给予安慰剂对VEMPs参数值没有实质性影响。

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