Ozluoglu Levent N, Akkuzu Guzin, Ozgirgin Nuri, Tarhan Erkan
Department of Otolaryngology, Baskent University, Ankara, Turkey.
Acta Otolaryngol. 2008 Apr;128(4):422-6. doi: 10.1080/00016480701808988.
The results of this preliminary study demonstrate that with regard to determining the efficacy of intratympanic (IT) gentamicin treatment in patients with Meniere's disease, the reliability of testing for vestibular evoked myogenic potentials (VEMPs) is comparable to that of caloric tests. Compared with caloric tests, VEMP measurements are more comfortable and take less time. The results of VEMP and caloric testing do not correlate with the results of hearing tests.
To test the reliability of VEMP testing to monitor the results of IT gentamicin therapy in patients with Meniere's disease.
Twelve patients with unilateral Meniere's disease were evaluated with pure tone audiometry (PTA), bithermal caloric tests, and VEMP tests. Patients with measurable caloric and VEMP results before IT gentamicin treatment were included in the study. IT gentamicin (0.5 ml) at a concentration of 40 mg/ml was administered to the patients. Reinjection was performed 10 days later depending on patients' complaints. Patients were re-evaluated with short- and long-term VEMP, hearing, and caloric test results.
Caloric responses and VEMPs changed following gentamicin therapy in 9 patients and 12 patients, respectively. Long-term results of caloric and VEMP tests in patients receiving IT gentamicin treatment changed in 7 patients and 10 patients, respectively.
这项初步研究的结果表明，在确定鼓室内注射庆大霉素治疗梅尼埃病患者的疗效方面，前庭诱发肌源性电位（VEMP）测试的可靠性与冷热试验相当。与冷热试验相比，VEMP测量更舒适且耗时更少。VEMP和冷热试验的结果与听力测试结果无关。
测试VEMP测试监测梅尼埃病患者鼓室内注射庆大霉素治疗效果的可靠性。
对12例单侧梅尼埃病患者进行纯音听力测定（PTA）、冷热试验和VEMP测试。研究纳入鼓室内注射庆大霉素治疗前冷热试验和VEMP结果可测量的患者。给患者注射浓度为40mg/ml的鼓室内庆大霉素（0.5ml）。10天后根据患者主诉进行再次注射。对患者进行短期和长期的VEMP、听力及冷热试验结果重新评估。
庆大霉素治疗后，分别有9例患者的冷热反应和12例患者的VEMP发生变化。接受鼓室内注射庆大霉素治疗患者的冷热试验和VEMP测试长期结果分别有7例和10例发生变化。
