An in vivo study of an antimicrobial mouth rinse on supragingival and subgingival plaque and calculus formation.

An antibiotic mouth rinse (CC10232) was used twice a day for one week in human subjects in a supervised double blind clinical and histological study. Nylon strips were placed supra and subgingivally for one week and then sectioned, stained and examined. Results showed that the rinse containing CC-10232 reduced the amount of plaque and reduced the amount of mineralization in 4 of 5 subjects.Also, no spirochetes were found in subjects who utilized this rinse.