Fine Daniel H, Markowitz Kenneth, Furgang David, Goldsmith Deborah, Charles Christine H, Lisante Toni Anne, Lynch Michael C
Department of Oral Biology, New Jersey Dental School, University of Dentistry and Medicine of New Jersey, Newark, NJ 07101, USA.
J Clin Periodontol. 2007 Aug;34(8):652-7. doi: 10.1111/j.1600-051X.2007.01096.x. Epub 2007 May 29.
This study was conducted to investigate the effect of rinsing with an essential oil-containing mouthrinse on levels of specific supra and subgingival bacteria in subjects with gingivitis.
Fifteen subjects meeting entry criteria completed this randomized, controlled, double-blind, crossover study. Subjects were required to have >or=1000 target organisms per millilitre in pooled samples from two subgingival sites. Following sampling of supra and subgingival plaque, subjects began twice-daily rinsing for 14 days with either an essential oil-containing mouthrinse (Cool Mint Listerine Antiseptic) or a negative control. Supra and subgingival plaque was again sampled on day 15, and the procedure repeated after a 1-week washout period with subjects using the alternate rinse.
Compared with the negative control, the essential oil mouthrinse produced significant reductions in supragingival plaque levels of Veillonella sp., Capnocytophaga sp., Fusobacterium nucleatum, and total anaerobes ranging from 52.3 to 88.5% (p<0.001 except for Veillonella, p=0.002); respective reductions in subgingival plaque ranged from 54.1 to 69.1% (p<0.001).
Rinsing with the essential oil mouthrinse can have an impact on the subgingival plaque flora. This study provides additional evidence indicating that reduction in supragingival plaque can reduce levels of subgingival plaque.
本研究旨在调查使用含精油漱口水对牙龈炎患者特定龈上和龈下细菌水平的影响。
15名符合入选标准的受试者完成了这项随机、对照、双盲、交叉研究。受试者在来自两个龈下部位的混合样本中每毫升需有≥1000个目标微生物。在采集龈上和龈下菌斑样本后，受试者开始每天两次用含精油漱口水（清凉薄荷李斯德林抗菌漱口水）或阴性对照进行漱口，持续14天。在第15天再次采集龈上和龈下菌斑样本，在为期1周的洗脱期后，受试者使用另一种漱口水重复该过程。
与阴性对照相比，含精油漱口水使韦荣球菌属、二氧化碳嗜纤维菌属、具核梭杆菌和总厌氧菌的龈上菌斑水平显著降低，降低幅度为52.3%至88.5%（除韦荣球菌属外，p<0.001，韦荣球菌属p = 0.002）；龈下菌斑的相应降低幅度为54.1%至69.1%（p<0.001）。
使用含精油漱口水可对龈下菌斑菌群产生影响。本研究提供了额外证据，表明龈上菌斑的减少可降低龈下菌斑水平。
