Vinzio S, Andres E, Goichot B, Schlienger J L
Service de Médecine Interne et Nutrition, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, avenue Molière, 67098 Strasbourg Cedex.
Ann Med Interne (Paris). 2000 Jun;151(4):309-10.
Guillain-Barré syndrome subsequent to Mycoplasma pneumoniae is uncommon and difficult to confirm. We report one case. Clinical presentation and therapy were unremarkable. The interest of antibiotics (preventive or curative) is unresolved. The pathophysiology remains hypothetical but Mycoplasma pneumoniae and some surface gangliosides of peripheral nerves share homologous epitopes leading to the production of antibodies. Induced antibodies to ganglioside may cross-react with neural tissues.
肺炎支原体感染后并发吉兰 - 巴雷综合征并不常见且难以确诊。我们报告一例。临床表现及治疗过程无特殊之处。抗生素(预防性或治疗性)的作用尚无定论。其病理生理学仍为假说,但肺炎支原体与周围神经的某些表面神经节苷脂具有共同的表位,可导致抗体产生。诱导产生的抗神经节苷脂抗体可能与神经组织发生交叉反应。