Ito C S, Scher A M
Circ Res. 1979 Jul;45(1):26-34. doi: 10.1161/01.res.45.1.26.
After cervical aortic nerve section, mean arterial pressure in the unanesthetized dog increased by an average of 7.4 mm Hg. Following a more extensive denervation of aortic arch receptors by section of intrathoracic vagal branches, arterial pressure increased by 16.7 mm Hg. The above changes were seen in the stable state after the effects of surgery had disappeared. In both cases carotid baroreceptors were functional. After administration of nitroglycerin and phenylephrine subsequent to either denervation procedure, blood pressure changes were larger and heart rate responses were smaller than in the control state. The unanesthetized dog regulates mean arterial pressure at a higher-than-normal pressure after aortic baroreceptor denervation. Reflexes from the aortic baroreceptors continuously participate in the normal control of mean arterial pressure. Section of the cervical aortic nerves only partially denervates aortic baroreceptors. Our findings may be relevant to human essential hypertension.
切断颈主动脉神经后，未麻醉犬的平均动脉压平均升高7.4毫米汞柱。通过切断胸段迷走神经分支对主动脉弓感受器进行更广泛的去神经支配后，动脉压升高了16.7毫米汞柱。上述变化在手术影响消失后的稳定状态下可见。在这两种情况下，颈动脉压力感受器均功能正常。在任何一种去神经支配程序后给予硝酸甘油和去氧肾上腺素后，血压变化比对照状态下更大，心率反应比对照状态下更小。未麻醉犬在主动脉压力感受器去神经支配后将平均动脉压调节在高于正常的压力水平。来自主动脉压力感受器的反射持续参与平均动脉压的正常调节。切断颈主动脉神经仅部分去除了主动脉压力感受器的神经支配。我们的发现可能与人类原发性高血压有关。
