Sánchez G, Vila L, Pajarón M, Diéguez I
Department of Allergology and Clinical Immunology, University Clinic, Faculty of Medicine, University of Navarra, Pamplona, Spain.
J Investig Allergol Clin Immunol. 2000 May-Jun;10(3):170-2.
Serum sickness consists of a systemic reaction resulting from the formation of soluble circulating immunocomplexes after the introduction of a foreign substance into the body We studied a 38-year-old woman diagnosed with anxiety, depression and right sacroileitis who was treated with phenylbutazone, ranitidine, clomipramine and levomepromazine. After taking this treatment for 1 month, she presented with fever, diarrhea, localized edemas, generalized pruritic papular and erythematous rash and lymphadenopathies. She presented the same symptoms after oral intake of metamizole. The diagnosis was confirmed following a single-blind, placebo-controlled provocation test with phenylbutazone and a biopsy of the affected skin.
血清病是由于外来物质进入体内后形成可溶性循环免疫复合物而导致的一种全身反应。我们研究了一名38岁女性，她被诊断患有焦虑症、抑郁症和右骶髂关节炎，接受了保泰松、雷尼替丁、氯米帕明和左美丙嗪治疗。服用这种治疗药物1个月后，她出现发热、腹泻、局部水肿、全身性瘙痒性丘疹和红斑疹以及淋巴结病。口服安乃近后她出现了相同症状。通过保泰松单盲、安慰剂对照激发试验和对受影响皮肤进行活检后确诊。
