气相色谱法测定血浆中格列本脲的含量。
Gas chromatographic determination of glibenclamide in plasma.
作者信息
Castoldi D, Tofanetti O
出版信息
Clin Chim Acta. 1979 Apr 16;93(2):195-8. doi: 10.1016/0009-8981(79)90088-3.
PMID:109236
Abstract
A gas-chromatographic method for glibenclamide determination in plasma is described. It involves derivatization of the drug with dinitrofluorobenzene and the use of an electron-capture detector. The quantitative evaluation is performed using tolbutamide as internal standard. Characteristics and specificity of the method for the principal metabolite of glibenclamide are examined.
摘要
本文描述了一种用于测定血浆中格列本脲的气相色谱法。该方法包括用二硝基氟苯对药物进行衍生化，并使用电子捕获检测器。以甲苯磺丁脲作为内标进行定量评估。对该方法用于格列本脲主要代谢物的特性和特异性进行了研究。
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