Martin J N, May W L, Rinehart B K, Martin R W, Magann E F
Department of Obstetrics and Gynecology and Preventive Medicine, University of Mississippi Medical Center, Jackson 39216-4505, USA.
South Med J. 2000 Jul;93(7):686-91.
Maternal obesity is a risk factor for severe preeclampsia. We sought to ascertain whether a similar relationship exists between maternal weight and HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) as an atypical form of severe preeclampsia.
In this retrospective investigation, 434 patients with HELLP syndrome were assigned to one of four study groups according to maternal weight and were analyzed in relation to selected maternal and perinatal data reflective of disease severity.
We found no significant associations between maternal weight and parameters of HELLP syndrome severity, race, delivery mode, gestational age, or perinatal outcome. Significantly associated with increasing maternal weight were maternal age, parity, admission mean arterial pressure, peak peripartum systolic blood pressures, concurrent essential hypertension, and the interval between admission and delivery. Inversely associated were eclampsia and the interval between delivery and discharge.
Severity and complications attendant with HELLP syndrome appear unrelated to maternal weight. Paradoxically, eclampsia occurs most commonly in the lighter gravida with HELLP syndrome.
孕妇肥胖是重度子痫前期的一个风险因素。我们试图确定孕妇体重与作为重度子痫前期非典型形式的HELLP综合征（溶血、肝酶升高和血小板减少）之间是否存在类似关系。
在这项回顾性研究中，434例HELLP综合征患者根据孕妇体重被分为四个研究组之一，并针对反映疾病严重程度的选定孕妇和围产期数据进行分析。
我们发现孕妇体重与HELLP综合征严重程度参数、种族、分娩方式、孕周或围产期结局之间无显著关联。与孕妇体重增加显著相关的因素有孕妇年龄、产次、入院平均动脉压、分娩期最高收缩压、并发原发性高血压以及入院至分娩的间隔时间。与孕妇体重增加呈负相关的因素是子痫以及分娩至出院的间隔时间。
HELLP综合征的严重程度及相关并发症似乎与孕妇体重无关。矛盾的是，子痫最常发生于患有HELLP综合征的体重较轻的孕妇。
