Aliaga E, Cárcamo C, Abarca J, Tapia-Arancibia L, Bustos G
Laboratorio de Farmacología-Bioquímica, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago.
Brain Res Mol Brain Res. 2000 Jun 23;79(1-2):150-5. doi: 10.1016/s0169-328x(00)00095-4.
By using non-isostopic in situ hybridization we have demonstrated a transient increase of BDNF mRNA in the lateral subregion of the substantia nigra pars reticulata 1 week after intrastriatal application of 6-OH-DA. These changes correlate with a partial reduction of dopamine (DA) content in the striatum but with a normal tyrosine hydroxylase immunoreactivity in substantia nigra pars compacta. Our data suggest that non-DA, BDNF expressing cells in substantia nigra pars reticulata may play a role in neuronal protection after partial lesions of the DA nigrostriatal pathway.
通过使用非同位素原位杂交技术，我们发现在纹状体内注射6-羟基多巴胺（6-OH-DA）1周后，黑质网状部外侧亚区的脑源性神经营养因子（BDNF）信使核糖核酸（mRNA）出现短暂增加。这些变化与纹状体内多巴胺（DA）含量的部分降低相关，但黑质致密部的酪氨酸羟化酶免疫反应性正常。我们的数据表明，黑质网状部中表达BDNF的非多巴胺能细胞可能在多巴胺黑质纹状体通路部分损伤后的神经元保护中发挥作用。
