Sharapov M B, Favorov M O, Iashina T L, Onishchenko G G, Asadov D A, Chorba T L
Pediatric Medical Institute, Tashkent, Uzbekistan.
Zh Mikrobiol Epidemiol Immunobiol. 2000 May-Jun(3):35-9.
Official annual statistical data on morbidity in acute viral hepatitides (AVH), including the number of lethal cases, for 1985-1995 were analyzed. Mortality rates per 100,000 of the population at the period of 11 years were calculated for different age groups, sex and the place of residence. 396 and 99 patients were examined for the presence of serological markers of hepatitides A, B and E, respectively, at the periods of epidemic rises in morbidity and satisfactory epidemic situation. In the course of 11 years AVH caused the death of 22,405 persons. In 1985-1987 the average mortality level (ML) reached 12.3-17.8 per 100,000 of the population (with morbidity being 1,200-1,400 and was essentially higher among the rural population in comparison with the urban population. During these years the highest ML, was registered among children aged 0-2 years (190-50 per 100,000) and, among adults, mainly among women aged 20-29 years (21.4-19.6 per 100,000). During the years when the epidemic of AVH was absent, ML among these groups was essentially lower: 40-20 among children aged 0-2 years and 4-5 among women aged 20-29 years. In 1987 in the Fergana Valley hepatitis E was detected in 72.2% of all examined patients, and in the southern areas of the country in 68.7%. A sharp rise on mortality among women of the productive age at the period of the epidemic rise of AVH morbidity in the endemic region indicated that this epidemic was linked with hepatitis E. High ML among young children may be indicative of a highly unfavorable course of hepatitis E in the group of infants, which had never been registered before. This newly established regularity may be used for the retrospective diagnostics of the outbreak of hepatitis E.
分析了1985 - 1995年急性病毒性肝炎（AVH）发病率的官方年度统计数据，包括死亡病例数。计算了11年间不同年龄组、性别和居住地每10万人的死亡率。在发病率上升期和疫情平稳期，分别对396例和99例患者进行了甲型、乙型和戊型肝炎血清学标志物检测。在11年中，AVH导致22405人死亡。1985 - 1987年，平均死亡率（ML）达到每10万人12.3 - 17.8例（发病率为1200 - 1400例），农村人口的死亡率明显高于城市人口。在这些年里，0 - 2岁儿童的死亡率最高（每10万人190 - 50例），在成年人中，主要是20 - 29岁女性的死亡率最高（每10万人21.4 - 19.6例）。在没有AVH疫情的年份，这些组别的死亡率明显较低：0 - 2岁儿童为40 - 20例，20 - 29岁女性为4 - 5例。1987年，在费尔干纳谷地，72.2%的受检患者检测出戊型肝炎，在该国南部地区为68.7%。在地方性流行地区，AVH发病率上升期，育龄妇女死亡率急剧上升，表明此次疫情与戊型肝炎有关。幼儿中高死亡率可能表明戊型肝炎在婴儿群体中病程极为不利，这在以前从未有过记录。这一新发现规律可用于戊型肝炎疫情爆发的回顾性诊断。
