Iarasheva D M, Shakhgil'dian I V, Aripov Kh Ia, Psarev V M, Kurbanov M D, Akhmedov U A, Dzhumaev R B, Madaliev I M
Zh Mikrobiol Epidemiol Immunobiol. 1993 Mar-Apr(2):63-6.
On the basis of the results of the retrospective epidemiological analysis of hepatitis A morbidity for many years in the Leninabad (now Hojend) region of Tajikistan the possibility of the epidemiological diagnosis of fecal-oral hepatitis non A, non B, also known as hepatitis E, was confirmed. Analysis of the specific features of a sharp morbidity rise in hepatitis A in this region in 1986-1987 made it possible to establish that this rise was caused by hepatitis E. This was testified by the explosive character of morbidity; the prevalence of persons aged 15-29 years, found to have antibodies to hepatitis A virus in 95% of cases (among patients, these persons constituted 67.5% of the total number of hepatitis A patients and children of preschool age constituted only 8.8% of such patients); sharply pronounced irregularity in the distribution of morbidity in individual settlements, depending on the state of water supply; a low number of the foci of infection in patient's families; the unfavorable course of the disease in pregnant women with high mortality rate (19%) among them. Similar epidemiological features were noted in hepatitis E outbreaks, occurring at the same period in the adjoining regions in Kirghizia and Uzbekistan, where the etiology of the disease was established by excluding the markers of hepatitides A and B in most of the patients. Some data indicate that the causes of these outbreaks of hepatitis E were linked with the water route of the transmission of hepatitis E virus.
根据对塔吉克斯坦列宁纳巴德（现霍真德）地区多年来甲型肝炎发病率的回顾性流行病学分析结果，证实了对粪 - 口传播的非甲非乙型肝炎（即戊型肝炎）进行流行病学诊断的可能性。对该地区1986 - 1987年甲型肝炎发病率急剧上升的特点进行分析后发现，这种上升是由戊型肝炎引起的。发病率的爆发特征；15 - 29岁人群的患病率，95%的病例检测出甲型肝炎病毒抗体（在患者中，这些人占甲型肝炎患者总数的67.5%，而学龄前儿童仅占此类患者的8.8%）；发病率在各个定居点的分布明显不均衡，取决于供水状况；患者家庭中感染源数量较少；孕妇病情严重，死亡率较高（19%）。吉尔吉斯斯坦和乌兹别克斯坦毗邻地区同期发生的戊型肝炎疫情也出现了类似的流行病学特征，在大多数患者中通过排除甲型和乙型肝炎标志物确定了疾病的病因。一些数据表明，这些戊型肝炎疫情的原因与戊型肝炎病毒的水传播途径有关。
