盐酸硫胺对铅诱导的大鼠肝脏和肾脏脂质过氧化的影响。
Effect of thiamine hydrochloride on lead induced lipid peroxidation in rat liver and kidney.
作者信息
Senapati S K, Dey S, Dwivedi S K, Patra R C, Swarup D
机构信息
Division of Medicine, Indian Veterinary Research Institute, Izatnagar.
出版信息
Vet Hum Toxicol. 2000 Aug;42(4):236-7.
Thiamine hydrochloride was studied on lead-induced endogenous lipid peroxidation in rat hepatic and renal tissues following po doses of 2.73 mg lead/kg bw for 6 w. Simultaneous use of 25 mg thiamine hydrochloride/kg bw po reduced lead accumulation in liver and kidneys. There were significant decreases in endogenous lipid peroxide in liver and kidney from thiamine hydrochloride-treated rats. Histopathological lesions in thiamine-treated livers and kidneys were milder in comparison to lesions in untreated Pb-exposed animals. This indicates the prophylactic potential of thiamine for lead-induced lipid peroxidation.
研究了盐酸硫胺对大鼠经口给予2.73mg铅/kg体重，持续6周后肝和肾组织中铅诱导的内源性脂质过氧化的影响。同时经口给予25mg盐酸硫胺/kg体重可减少肝脏和肾脏中铅的蓄积。盐酸硫胺处理的大鼠肝脏和肾脏中的内源性脂质过氧化物显著减少。与未处理的铅暴露动物相比，盐酸硫胺处理的肝脏和肾脏的组织病理学损伤较轻。这表明硫胺对铅诱导的脂质过氧化具有预防潜力。
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