Fuchs K H
Chirurgische Universitätsklinik Würzburg.
Zentralbl Chir. 2000;125(5):443-9.
Barrett-carcinoma is a type of adenocarcinoma of the distal esophagus and the cardia. Barrett-esophagus is defined by the histologic presence of specialized epithelium with intestinal metaplasia. As a consequence Barrett-carcinoma has a close relationship to the adenocarcinoma of the cardia and is very often part of the cardiacarcinoma type I. The aim of the surgical therapy is a radical R0-resection of the tumor including the lymphatic drainage area. This aim is accomplished among different authors by different surgical concepts. One is the radical transhiatal subtotal esophagectomy with lymphadenectomy in the lower mediastinum and the upper abdominal compartments. The other concept is a transthoracic en-bloc esophagectomy. Both resection procedures are usually completed by gastric pull up reconstruction. Currently a sophisticated preoperative staging is followed by distinguished indication and therapy depending on tumor status, risk factors of the patient and on the international classification of the cardia carcinoma (Siewert). When a R0-resection is impossible, a neoadjuvant radiochemotherapy should be performed.
巴雷特食管癌是一种远端食管和贲门的腺癌。巴雷特食管由具有肠化生的特殊上皮组织学存在来定义。因此,巴雷特食管癌与贲门腺癌关系密切,且常是I型贲门癌的一部分。手术治疗的目的是对肿瘤进行根治性R0切除,包括淋巴引流区。不同作者通过不同的手术理念实现这一目标。一种是经裂孔根治性次全食管切除术,同时清扫下纵隔和上腹部区域的淋巴结。另一种理念是经胸整块食管切除术。两种切除手术通常都通过胃上提重建来完成。目前,完善的术前分期之后,会根据肿瘤状态、患者风险因素以及贲门癌的国际分类(西韦特分类)进行明确的适应症选择和治疗。当无法进行R0切除时,应进行新辅助放化疗。