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药物糖科学中的新兴主题。

Emerging themes in medicinal glycoscience.

作者信息

Koeller K M, Wong C H

机构信息

Department of Chemistry, The Scripps Research Institute and Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA.

出版信息

Nat Biotechnol. 2000 Aug;18(8):835-41. doi: 10.1038/78435.

Abstract

The recognition of complex carbohydrates and glycoconjugates as mediators of important biological processes has stimulated investigation into their therapeutic potential. New approaches for the simplification of glycoconjugate synthesis are overcoming the limitations of existing methods and providing a diverse array of these biomolecules. As the accessibility of glycoconjugates increases, carbohydrate-based constructs are becoming available for analysis as medicinal agents in a wide range of therapies.

摘要

复杂碳水化合物和糖缀合物作为重要生物过程的介质被认识,这激发了对其治疗潜力的研究。简化糖缀合物合成的新方法正在克服现有方法的局限性,并提供各种各样的这些生物分子。随着糖缀合物的可及性增加,基于碳水化合物的构建体正可用于作为多种疗法中的药物进行分析。

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