Khouzam H R, El-Gabalawi F
Department of Psychiatry, VAMC, Manchester, New Hampshire 03104-4098, USA.
J Child Adolesc Psychopharmacol. 2000 Summer;10(2):147-51. doi: 10.1089/cap.2000.10.147.
Bipolar I disorder is estimated to affect 0.6% of adolescents. Lithium, sodium valproate, carbamazapine, and adjunctive treatment with benzodiazapines and antipsychotics have been used to treat bipolar I disorders. We report a case of a 17-year-old adolescent male with bipolar I disorder who responded favorably to the treatment with the atypical antipsychotic olanzapine. We hypothesize that olanzapine's broad affinity for both dopaminergic and serotonergic receptors may be related to the beneficial therapeutic outcome.
据估计，双相I型障碍在青少年中的发病率为0.6%。锂盐、丙戊酸钠、卡马西平以及联用苯二氮卓类药物和抗精神病药物已被用于治疗双相I型障碍。我们报告了一例17岁双相I型障碍青少年男性患者，其使用非典型抗精神病药物奥氮平治疗效果良好。我们推测，奥氮平对多巴胺能和5-羟色胺能受体的广泛亲和力可能与良好的治疗效果有关。
