VON Eiff C, Overbeck J, Haupt G, Herrmann M, Winckler S, Richter K-D, Peters G, Spiegel H-U
Institute of Medical Microbiology, *Department of Trauma- and Hand-Surgery, †Central Animal Experimentation Facility, ‡Department of General Surgery - Surgical Research, Westfälische Wilhelms-Universität Münster, 48149 Münster and §Department of Urology, Ruhr-Universität Bochum, 44627 Herne, Germany.
J Med Microbiol. 2000 Aug;49(8):709-712. doi: 10.1099/0022-1317-49-8-709.
Despite considerable knowledge about the effects of shock waves on eukaryotic soft tissues, no data are available concerning their effect on prokaryotic micro-organisms. In vitro studies on the bactericidal effect of extracorporeal shock waves on staphylococci were performed with energy levels that are standard for the disintegration of calculi. Suspensions containing 10(4)-10(5) cfu of Staphylococcus aureus/ml were sealed in plastic tubes and exposed to shock waves, resulting in a mean decrease of 3.1 log(10). Whereas impulse rates of > or =350 resulted in a decrease of cfu/ml equalling the detection limit, lower numbers of impulses did not result in an appreciable bactericidal effect. The bactericidal effect of extracorporeal shock waves might provide the basis for the development of novel therapeutic strategies for bacterial infections.
尽管对于冲击波对真核软组织的影响已有相当多的了解，但关于其对原核微生物的影响尚无数据。我们使用了用于结石分解的标准能量水平，对体外冲击波对葡萄球菌的杀菌作用进行了研究。将含有每毫升10(4)-10(5) 菌落形成单位（cfu）的金黄色葡萄球菌悬浮液密封在塑料管中，并使其暴露于冲击波下，导致平均下降3.1个对数（10）。当脉冲率≥350时，cfu/ml的下降等于检测限，而较低的脉冲数则未产生明显的杀菌效果。体外冲击波的杀菌作用可能为开发新型细菌感染治疗策略提供基础。
