用于造血祖细胞和乳腺细胞的小鼠乳腺肿瘤病毒转录增强子具有共同的功能元件。
The mouse mammary tumor virus transcription enhancers for hematopoietic progenitor and mammary gland cells share functional elements.
作者信息
Reuss F U, Coffin J M
机构信息
Forschungsschwerpunkt Angewandte Tumorvirologie F0400, 69120 Heidelberg, Germany.
出版信息
J Virol. 2000 Sep;74(17):8183-7. doi: 10.1128/jvi.74.17.8183-8187.2000.
Abstract
Expression of mouse mammary tumor virus (MMTV)-encoded superantigens in B lymphocytes is required for viral transmission and pathogenesis. We have previously established a critical role of an enhancer element within the long terminal repeat (LTR) for MMTV sag gene expression in B-lymphoid progenitor cells. We now demonstrate enhancer activity of this element in a promyelocytic progenitor cell line. We also map the position of the enhancer within the U3 region of the MMTV LTR and show that the progenitor cell enhancer shares functional elements with a previously described mammary gland-specific enhancer.
摘要
小鼠乳腺肿瘤病毒（MMTV）编码的超抗原在B淋巴细胞中的表达是病毒传播和发病机制所必需的。我们之前已经确定了长末端重复序列（LTR）内的一个增强子元件在B淋巴细胞祖细胞中对MMTV sag基因表达的关键作用。我们现在证明了该元件在早幼粒细胞祖细胞系中的增强子活性。我们还绘制了MMTV LTR的U3区域内增强子的位置，并表明祖细胞增强子与先前描述的乳腺特异性增强子共享功能元件。
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Mammary gland expression of mouse mammary tumor virus is regulated by a novel element in the long terminal repeat.小鼠乳腺肿瘤病毒的乳腺表达受长末端重复序列中一个新元件的调控。
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Mouse mammary tumor virus superantigen expression in B cells is regulated by a central enhancer within the pol gene.小鼠乳腺肿瘤病毒超抗原在B细胞中的表达受pol基因内一个中央增强子的调控。
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Superantigen-induced immune stimulation amplifies mouse mammary tumor virus infection and allows virus transmission.超抗原诱导的免疫刺激会放大小鼠乳腺肿瘤病毒感染并促进病毒传播。
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Linkage of superantigen-like stimulation of syngeneic T cells in a mouse model of follicular center B cell lymphoma to transcription of endogenous mammary tumor virus.在滤泡中心B细胞淋巴瘤小鼠模型中，同基因T细胞的超抗原样刺激与内源性乳腺肿瘤病毒转录的关联。
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