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[抗氧化剂地布诺尔与μ-和δ-阿片受体激动剂在氧化应激期间心脏保护作用的比较分析]

[Comparative analysis of the cardioprotective effect of antioxidant dibunol and agonists of mu- and delta-opioid receptors during oxidative stress].

作者信息

Maslov L N, Rebrova T Iu

机构信息

Department of Experimental Cardiology, Russian Academy of Medical Sciences, Tomsk, Russia.

出版信息

Eksp Klin Farmakol. 2000 May-Jun;63(3):24-8.

PMID:10934591
Abstract

Upon intravenous injection of the delta-opioid receptor agonists, the isolated perfused rat heart became resistant to free radical damage. The cardioprotector activity of the delta-receptor agonists is more pronounced than that of the antioxidant dibunol. Both dibunol and the delta-receptor agonists favored a decrease in the level of diene conjugates in myocardium. Stimulation of the mu-opioid receptors did not change the resistance of rat heart to the oxidative stress.

摘要

静脉注射δ-阿片受体激动剂后，离体灌注的大鼠心脏对自由基损伤产生抗性。δ-受体激动剂的心脏保护活性比抗氧化剂二丁诺更显著。二丁诺和δ-受体激动剂均有助于降低心肌中二烯共轭物的水平。刺激μ-阿片受体并未改变大鼠心脏对氧化应激的抗性。

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