Jordan W P, Bourlas M C
Arch Dermatol. 1975 May;111(5):593-5.
Six subjects, allergic to the elastic in their undergarments, were patch test-negative to the rubber components and new elastic from the suppliers. However, washing the rubber with sodium hypochlorite gave the subjects allergic responses due to the effect of bleach on the rubber accelerator, zinc dibenzyldithiocarbamate (ZDC). To identify the allergen, ZDC was reacted with the sodium hypochlorite, and the resultant gum was extracted with diethyl ether. Eight compounds were identified in the reaction mixture by gas chromatography-mass spectrometry. The individual components were tested on volunteers after sensitization to the reaction mixture was produced in 14 of 25 volunteers. One component, N,N-dibenzylcarbamyl chloride produced an allergic response in each sensitized volunteer.
六名对其内衣弹性材料过敏的受试者，对橡胶成分和供应商提供的新型弹性材料进行斑贴试验呈阴性。然而，用次氯酸钠洗涤橡胶会使受试者产生过敏反应，这是由于漂白剂对橡胶促进剂二苄基二硫代氨基甲酸锌（ZDC）的作用所致。为了鉴定过敏原，使ZDC与次氯酸钠反应，然后用乙醚萃取所得的胶状物。通过气相色谱-质谱联用仪在反应混合物中鉴定出八种化合物。在25名志愿者中有14名对反应混合物产生致敏后，对这些个体成分在志愿者身上进行了测试。一种成分，N，N-二苄基氨基甲酰氯在每一名致敏志愿者身上都引发了过敏反应。
