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Implications of mapping the human telomerase gene (hTERT) as the most distal gene on chromosome 5p.

作者信息

Shay J W, Wright W E

机构信息

Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas 75390-9039, USA.

出版信息

Neoplasia. 2000 May-Jun;2(3):195-6. doi: 10.1038/sj.neo.7900093.

DOI:10.1038/sj.neo.7900093
PMID:10935504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1507567/
Abstract
摘要

相似文献

1
Implications of mapping the human telomerase gene (hTERT) as the most distal gene on chromosome 5p.将人类端粒酶基因（hTERT）定位为5号染色体短臂上最远端基因的意义。
Neoplasia. 2000 May-Jun;2(3):195-6. doi: 10.1038/sj.neo.7900093.
2
Mapping of the gene for the human telomerase reverse transcriptase, hTERT, to chromosome 5p15.33 by fluorescence in situ hybridization.通过荧光原位杂交将人类端粒酶逆转录酶基因（hTERT）定位于染色体5p15.33。
Neoplasia. 2000 May-Jun;2(3):197-201. doi: 10.1038/sj.neo.7900092.
3
E2F-1 represses transcription of the human telomerase reverse transcriptase gene.E2F-1抑制人类端粒酶逆转录酶基因的转录。
Nucleic Acids Res. 2001 Jul 1;29(13):2789-94. doi: 10.1093/nar/29.13.2789.
4
Regulation of human telomerase activity: repression by normal chromosome 3 abolishes nuclear telomerase reverse transcriptase transcripts but does not affect c-Myc activity.人类端粒酶活性的调控：正常3号染色体的抑制作用可消除细胞核端粒酶逆转录酶转录本，但不影响c-Myc活性。
Cancer Res. 2001 Oct 15;61(20):7594-602.
5
Human chromosome 5 carries a transcriptional regulator of human telomerase reverse transcriptase (hTERT).人类染色体 5 携带人类端粒酶逆转录酶 (hTERT) 的转录调节剂。
Biochem Biophys Res Commun. 2010 Aug 6;398(4):695-701. doi: 10.1016/j.bbrc.2010.07.003. Epub 2010 Jul 16.
6
Human telomerase reverse transcriptase promoter regulation in normal and malignant human ovarian epithelial cells.正常与恶性人卵巢上皮细胞中人类端粒酶逆转录酶启动子调控
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7
A chromosome 3-encoded repressor of the human telomerase reverse transcriptase (hTERT) gene controls the state of hTERT chromatin.人类端粒酶逆转录酶（hTERT）基因的3号染色体编码的阻遏物控制着hTERT染色质的状态。
Cancer Res. 2003 Feb 1;63(3):689-95.
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Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene.人端粒酶逆转录酶基因启动子区域的克隆与鉴定
Cancer Res. 1999 Feb 15;59(4):826-30.
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Human chromosome 5 carries a putative telomerase repressor gene.人类5号染色体携带着一个假定的端粒酶抑制基因。
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Rearrangements of minisatellites in the human telomerase reverse transcriptase gene are not correlated with its expression in colon carcinomas.人端粒酶逆转录酶基因中微卫星的重排与结肠癌中该基因的表达无关。
Oncogene. 2001 May 3;20(20):2600-5. doi: 10.1038/sj.onc.1204346.

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Long-range telomere regulation of gene expression: Telomere looping and telomere position effect over long distances (TPE-OLD).长距离端粒调控基因表达：端粒环化和长距离端粒位置效应（TPE-OLD）。
Differentiation. 2018 Jan-Feb;99:1-9. doi: 10.1016/j.diff.2017.11.005. Epub 2017 Nov 22.
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Role of Telomeres and Telomerase in Aging and Cancer.端粒与端粒酶在衰老和癌症中的作用。
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Alternative lengthening of telomeres: recurrent cytogenetic aberrations and chromosome stability under extreme telomere dysfunction.端粒的替代性延长：端粒功能极度失调下的反复细胞遗传学异常和染色体稳定性。
Neoplasia. 2013 Nov;15(11):1301-13. doi: 10.1593/neo.131574.
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Are short telomeres predictive of advanced cancer?端粒较短是否预示着癌症晚期？
Cancer Discov. 2013 Oct;3(10):1096-8. doi: 10.1158/2159-8290.CD-13-0506.
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Chromosome arm-specific long telomeres: a new clonal event in primary chronic myelogenous leukemia cells.染色体臂特异性长端粒：原发性慢性髓细胞性白血病细胞中的一个新的克隆事件。
Neoplasia. 2011 Jun;13(6):550-60. doi: 10.1593/neo.11358.
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Transcriptional silencing of a novel hTERT reporter locus during in vitro differentiation of mouse embryonic stem cells.小鼠胚胎干细胞体外分化过程中新型hTERT报告基因位点的转录沉默
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本文引用的文献

1
Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?时间、端粒与肿瘤：细胞衰老是否不止是一种抗癌机制？
Trends Cell Biol. 1995 Aug;5(8):293-7. doi: 10.1016/s0962-8924(00)89044-3.
2
Mapping of the gene for the human telomerase reverse transcriptase, hTERT, to chromosome 5p15.33 by fluorescence in situ hybridization.通过荧光原位杂交将人类端粒酶逆转录酶基因（hTERT）定位于染色体5p15.33。
Neoplasia. 2000 May-Jun;2(3):197-201. doi: 10.1038/sj.neo.7900092.
3
Cri du chat syndrome: changing phenotype in older patients.猫叫综合征：老年患者的表型变化
Am J Med Genet. 2000 Jan 31;90(3):203-15. doi: 10.1002/(sici)1096-8628(20000131)90:3<203::aid-ajmg5>3.0.co;2-a.
4
Hemizygosity of delta-catenin (CTNND2) is associated with severe mental retardation in cri-du-chat syndrome.δ-连环蛋白（CTNND2）半合子不足与猫叫综合征中的严重智力障碍相关。
Genomics. 2000 Jan 15;63(2):157-64. doi: 10.1006/geno.1999.6090.
5
A telomerase component is defective in the human disease dyskeratosis congenita.端粒酶的一个组分在人类疾病先天性角化不良中存在缺陷。
Nature. 1999 Dec 2;402(6761):551-5. doi: 10.1038/990141.
6
Telomerase activity and human papillomavirus (HPV) infection in human uterine cervical cancers and cervical smears.人子宫颈癌及宫颈涂片中的端粒酶活性与人乳头瘤病毒（HPV）感染
Eur J Cancer. 1998 Dec;34(13):2082-6. doi: 10.1016/s0959-8049(98)00242-1.
7
Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation.端粒酶逆转录酶基因是c-Myc的直接靶点，但在细胞转化中功能并不等同。
Oncogene. 1999 Feb 4;18(5):1219-26. doi: 10.1038/sj.onc.1202669.
8
Direct activation of TERT transcription by c-MYC.c-MYC对端粒酶逆转录酶（TERT）转录的直接激活。
Nat Genet. 1999 Feb;21(2):220-4. doi: 10.1038/6010.
9
Repression of the telomerase catalytic subunit by a gene on human chromosome 3 that induces cellular senescence.人类3号染色体上一个诱导细胞衰老的基因对端粒酶催化亚基的抑制作用。
Mol Carcinog. 1998 Jun;22(2):65-72. doi: 10.1002/(sici)1098-2744(199806)22:2<65::aid-mc1>3.0.co;2-j.
10
Myc activates telomerase.Myc激活端粒酶。
Genes Dev. 1998 Jun 15;12(12):1769-74. doi: 10.1101/gad.12.12.1769.