Weiss M, Ben Shlomo A, Hagag P, Rapoport M, Ish-Shalom S
Endocrine Institute, 'Assaf Harofeh' Medical Center, 70300, Zerifin, Israel.
Maturitas. 2000 Jun 30;35(3):237-43. doi: 10.1016/s0378-5122(00)00124-9.
To evaluate the effect of estrogen replacement therapy (ERT) on postmenopausal bone loss by multi-site ultrasound measurement.
A cross-sectional comparison of postmenopausal women, ERT users and non-users. The two study groups were enrolled for the reference database collection for the Sunlight Omnisense (Omnisense) and were matched by years since menopause. Speed of sound (SOS) was measured at the distal radius (RAD), mid-shaft tibia (TIB), fifth metatarsus (MTR) and proximal phalanx (PLX).
143 ERT users for 5.2+/-3.6 years were compared with 139 ERT non-users (age: 57.0+/-5.3 and 57.5+/-5.5, respectively). Both groups were 7.1+/-5.0 years since menopause. SOS, expressed in T-score units, was higher at the RAD in ERT users as compared to ERT non-users (-0.55+/-1.30 and -1.36+/-1.60, respectively, P<0.0001), and at the TIB (-0.73+/-1.34 and -1.28+/-1.45, respectively, P=0. 003). Same trend was observed at the MTR and PLX, but not statistically significant because of fewer observations. In early post menopause period, the ERT-non users RAD data shows an annual SOS decrease of 0.17 versus annual increase of 0.12 T-score units (P=0.037). Similar effect is observed at the TIB, though not statistically significant (non-users decrease of 0.20 vs. users increase of 0.08 T-score units/year, P=0.086).
SOS measurements by Omnisense at multiple skeletal sites support the ERT protective effect on bone.
通过多部位超声测量评估雌激素替代疗法（ERT）对绝经后骨质流失的影响。
对绝经后女性、ERT使用者和非使用者进行横断面比较。两个研究组被纳入阳光全知（Omnisense）参考数据库收集，并根据绝经年限进行匹配。在桡骨远端（RAD）、胫骨中段（TIB）、第五跖骨（MTR）和近端指骨（PLX）测量声速（SOS）。
将143名使用ERT 5.2±3.6年的使用者与139名未使用ERT者（年龄分别为57.0±5.3岁和57.5±5.5岁）进行比较。两组绝经年限均为7.1±5.0年。以T值单位表示的SOS，ERT使用者在RAD处高于未使用者（分别为-0.55±1.30和-1.36±1.60，P<0.0001），在TIB处也更高（分别为-0.73±1.34和-1.28±1.45，P=0.003）。在MTR和PLX处观察到相同趋势，但由于观察次数较少，无统计学意义。在绝经后早期，未使用ERT者的RAD数据显示SOS每年下降0.17，而使用ERT者每年增加0.12 T值单位（P=0.037）。在TIB处观察到类似效果，尽管无统计学意义（未使用者每年下降0.20，使用者每年增加0.08 T值单位，P=0.086）。
Omnisense在多个骨骼部位进行的SOS测量支持ERT对骨骼的保护作用。
