Rocha Filho F D, Ferreira F V, Mendes F de O, Ferreira F N, Karbage A, Alencar M L, Costa D
Department of Pathology and Legal Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brasil.
Rev Soc Bras Med Trop. 2000 Jul-Aug;33(4):363-6. doi: 10.1590/s0037-86822000000400005.
Thirty cases of human kala-azar were diagnosed by iliac crest biopsy and myeloculture. Histological analysis of 12 patients showed diffuse thickening of reticulin fibers. To the best of our knowledge, this is the third report describing secondary bone marrow fibrosis (myelofibrosis-like) associated with kala-azar. Patients with positive bone marrow fibrosis (pbmf = 12) were compared to patients without detectable bone marrow fibrosis (wbmf = 18). There were no significant differences in clinical and blood parameters following treatment. All patients showed regression of hepatosplenomegaly. Our findings suggest that associated bone marrow fibrosis is transient and did not interfere in the evolution of treated patients.
通过髂嵴活检和骨髓培养诊断出30例人类黑热病。对12例患者的组织学分析显示网状纤维弥漫性增厚。据我们所知，这是第三篇描述与黑热病相关的继发性骨髓纤维化（类骨髓纤维化）的报告。将骨髓纤维化阳性患者（pbmf = 12）与未检测到骨髓纤维化的患者（wbmf = 18）进行比较。治疗后临床和血液参数无显著差异。所有患者的肝脾肿大均消退。我们的研究结果表明，相关的骨髓纤维化是短暂的，并未干扰接受治疗患者的病情发展。
