Valenti M P, Tinuper P, Cerullo A, Carcangiu R, Marini C
Neurological Institute, University of Sassari, Italy.
Epileptic Disord. 1999 Sep;1(3):167-71.
Reading epilepsy (RE) is a form of reflex epilepsy currently classified as an idiopathic localization-related epilepsy (ILAE, 1989).
We describe a 30 year-old right-handed male who suffered since the age of 8 from nocturnal partial motor seizures. Clinical features were typical of BECT. We reviewed the EEG recorded at that time which showed centrotemporal spike and waves. He was seizure-free from the age of 12 to the age of 17 when seizures evoked only by reading appeared. No other stimuli provoked seizures. Neurological and neuroradiological (CT and MR) investigations were normal. Baseline video-polygraphic EEG recordings were normal while reading aloud provoked myoclonic jerks in the facial muscles related to bilateral spike and wave discharges. Therapy with carbamazepine and valproic acid strongly reduced seizure frequency.
Recent papers have debated the difficulties in classifying RE among the generalized or focal syndromes. Literature reports describe an association with RE and juvenile myoclonic epilepsy, supporting the hypothesis of an idiopathic generalized form. We report the first documented case with a clear-cut idiopathic localization-related epilepsy evolving to a primary reading epilepsy.
阅读性癫痫（RE）是反射性癫痫的一种形式，目前被归类为特发性局灶性癫痫（国际抗癫痫联盟，1989年）。
我们描述了一名30岁的右利手男性，他从8岁起就患有夜间部分性运动性发作。临床特征符合儿童良性癫痫伴中央颞区棘波（BECT）。我们回顾了当时记录的脑电图，显示中央颞区有棘波和慢波。他在12岁至17岁期间无癫痫发作，之后仅在阅读时诱发癫痫发作。没有其他刺激可诱发癫痫发作。神经学和神经放射学（CT和MR）检查均正常。基线视频脑电图记录正常，但大声阅读会诱发面部肌肉的肌阵挛性抽搐，伴有双侧棘波和慢波放电。卡马西平和丙戊酸治疗显著降低了癫痫发作频率。
近期的论文讨论了在将阅读性癫痫归类于全身性或局灶性综合征时所面临的困难。文献报道描述了阅读性癫痫与青少年肌阵挛性癫痫之间的关联，支持了特发性全身性癫痫的假说。我们报告了首例有明确记录的从特发性局灶性癫痫演变为原发性阅读性癫痫的病例。
