Kling H
Fortschr Med. 1979 May 17;97(19):926-8.
In a multicentre study a total of 113 patients suffering from disturbed blood flow conditions of the lower extremities (type II Fontaine) were treated with butalamine hydrochloride tablets, each containing 80 mg of the active principle. In 96% of the cases given a daily dose of 3 x 2 tablets and in 82% of those treated with a daily dose of 3 x 1 tablet both subjective and objective clinical symptoms, such as walking distance and Ratschow's testing parameters, were found to be improved. In view of the findings that metabolic functions as well as systemic blood flow conditions were not affected and that the drug was furthermore well tolerated by the gastrointestinal system, butalamine hydrochloride proved to be an effective therapeutic in long-term treatment of patients suffering from blood flow disorders of the lower extremities.
在一项多中心研究中，共有113名患有下肢血流紊乱（II型Fontaine）的患者接受了每片含80毫克活性成分的盐酸布他拉明片治疗。在每日剂量为3×2片的病例中，96%以及在每日剂量为3×1片治疗的病例中82%，主观和客观临床症状，如行走距离和拉施乔测试参数，均有改善。鉴于代谢功能以及全身血流状况未受影响，且该药物在胃肠道系统中耐受性良好的研究结果，盐酸布他拉明被证明是治疗下肢血流紊乱患者的一种有效长期治疗药物。
