Lejeune M, Héron C, Tenenbaum F, Sarfati P O, Louvel A, Luton J P, Richard B
Service de Médecine nucléaire, Hôpital Cochin, Paris.
Presse Med. 2000;29(24):1345-7.
After thyroidectomy for differentiated thyroid carcinoma, extracervical uptake of iodine 131 is suggestive of metastasic dissemination. False positives can however occur.
Differentiated thyroid carcinoma was found in a female patient with a non-functional nodule. Two years after subtotal thyroidectomy and an ablative dose of iodine 131, the whole body scan showed abdominal mediastinal uptake with low serum thyroglobulin level. Considering the possibility of tumor recurrence or lymph node metastasis, the mass was excised. The histology diagnosis was mediastinal bronchogenic cyst.
To date, iodine uptake in a bronchogenic cyst has not been reported among other false-positives previously described. The pathophysiology of this iodine 131 uptake in a bronchogenic cyst is still unknown: the presence of NIS symporter or a protein which can organify iodine in the mucus cells of the cyst remains to be proven.
分化型甲状腺癌甲状腺切除术后，颈部以外区域摄取碘131提示转移扩散。然而，也可能出现假阳性结果。
一名患有无功能结节的女性患者被诊断为分化型甲状腺癌。甲状腺次全切除及碘131消融剂量治疗两年后，全身扫描显示腹部纵隔摄取，血清甲状腺球蛋白水平较低。考虑到肿瘤复发或淋巴结转移的可能性，切除了该肿物。组织学诊断为纵隔支气管源性囊肿。
迄今为止，支气管源性囊肿摄取碘的情况在之前描述的其他假阳性病例中尚未见报道。支气管源性囊肿摄取碘131的病理生理学机制仍不清楚：囊肿黏液细胞中是否存在钠碘同向转运体（NIS）或能使碘有机化的蛋白质仍有待证实。
