鼠伤寒沙门氏菌中一个大型基因重复的选择
Selection for a large genetic duplication in Salmonella typhimurium.
作者信息
Straus D S
出版信息
Genetics. 1975 Jun;80(2):227-37. doi: 10.1093/genetics/80.2.227.
Abstract
Salmonella typhimurium strains containing a duplication of nearly a third of the genome have been isolated by a simple procedure involving selection for improved utilization of L-malate as sole carbon source. The duplication occurs at a very high spontaneous frequency. Strains containing the duplication can be isolated selectively on malate medium, or by a non-selective procedure involving Hfr conjugation. When strains containing the duplication are maintained on non-selective medium, the duplication is readily lost. Genetic evidence suggests that the duplication is chromosomal and tandem. The fact that the recA gene is included in the duplication has been used to obtain evidence that the recA1 marker is recessive to its wild-type allele. Unlike tandem duplications previously described in I. coli, the duplication described in this report appears to have unique endpoints.
摘要
通过一种简单的程序，已分离出含有近三分之一基因组重复序列的鼠伤寒沙门氏菌菌株，该程序涉及选择以L-苹果酸作为唯一碳源时的利用改善情况。这种重复以非常高的自发频率发生。含有重复序列的菌株可以在苹果酸盐培养基上选择性分离，或者通过涉及高频重组（Hfr）接合的非选择性程序分离。当含有重复序列的菌株在非选择性培养基上维持时，重复序列很容易丢失。遗传证据表明这种重复是染色体的且是串联的。重复序列中包含recA基因这一事实已被用于获得recA1标记相对于其野生型等位基因是隐性的证据。与先前在大肠杆菌中描述的串联重复不同，本报告中描述的重复似乎具有独特的端点。
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