Perquin M, Oster T, Maul A, Froment N, Untereiner M, Bagrel D
Laboratoire de Biochimie, UFR SciFA, Université de Metz, Campus Bridoux, Rue Claude Bernard, 57070, Metz, France.
Cancer Lett. 2000 Sep 29;158(1):7-16. doi: 10.1016/s0304-3835(00)00481-x.
Glutathione and the associated enzymes, glutathione S-transferases, peroxidases, and reductase, have been implicated in cancer chemoresistance. This pathway was investigated in paired cancerous and peritumoral breast samples from 41 women. The tumours exhibited a higher redox status as deduced from increased transferase, peroxidase, and reductase activities and from higher total and reduced glutathione contents. Several components were strongly correlated in peritumoral tissues, suggesting a highly co-ordinated glutathione pathway that appeared disrupted in breast tumours with only a few correlations left. Therefore, resistance could spontaneously result from deregulated variations in the glutathione pathway, which might be relevant to the malignant disease progression.
谷胱甘肽以及相关酶类，如谷胱甘肽S-转移酶、过氧化物酶和还原酶，与癌症化疗耐药性有关。在41名女性的配对癌组织和瘤周乳腺样本中对该通路进行了研究。从转移酶、过氧化物酶和还原酶活性增加以及总谷胱甘肽和还原型谷胱甘肽含量升高可以推断，肿瘤表现出更高的氧化还原状态。瘤周组织中的几种成分高度相关，表明谷胱甘肽通路高度协调，而在乳腺肿瘤中该通路似乎被破坏，仅留下少数相关性。因此，耐药性可能自发地源于谷胱甘肽通路的失调变化，这可能与恶性疾病进展有关。
