Rolig R L, McKinnon P J
Dept of Genetics, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
Trends Neurosci. 2000 Sep;23(9):417-24. doi: 10.1016/s0166-2236(00)01625-8.
Many human pathological conditions with genetic defects in DNA damage responses are also characterized by neurological deficits. These neurological deficits can manifest themselves during many stages of development, suggesting an important role for DNA repair or processing during the development and maintenance of the nervous system. Although the molecular neuropathology associated with such deficits is largely unknown, many of the responsible gene defects have been identified. The current rapid progress in elucidation of molecular details following gene identification should provide further insight into the importance of DNA processing in nervous system function.
许多在DNA损伤反应中存在基因缺陷的人类病理状况也具有神经功能缺损的特征。这些神经功能缺损可在发育的多个阶段显现出来，这表明DNA修复或处理在神经系统的发育和维持过程中起着重要作用。尽管与这些缺损相关的分子神经病理学在很大程度上尚不清楚，但许多相关的基因缺陷已被识别出来。目前在基因识别后对分子细节的阐明方面取得的快速进展，应能进一步深入了解DNA处理在神经系统功能中的重要性。
