Amzel L M
Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2185, USA.
Methods Enzymol. 2000;323:167-77. doi: 10.1016/s0076-6879(00)23366-1.
Changes in configurational entropy represent one of the major contributions to the thermodynamics of folding, binding, and oligomerization. Methods have been developed to estimate changes in the entropy of the backbone and side chains, and for the loss of translational entropy. These methods have been used in combination with empirical methods that provide estimates of the changes in entropy of solvation as well as estimates of the changes of enthalpy. The results of such calculations are in excellent agreement with experimentally observed values.
构象熵的变化是折叠、结合和寡聚化热力学的主要贡献之一。已经开发出方法来估计主链和侧链熵的变化，以及平移熵的损失。这些方法已与经验方法结合使用，经验方法可提供溶剂化熵变化的估计值以及焓变化的估计值。此类计算结果与实验观测值非常吻合。
