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Activation of skin dendritic cells by immunostimulatory DNA.

作者信息

Vogel J C, Udey M C

机构信息

Dermatology Branch, National Cancer Institute, Bethesda, MD 20892, USA.

出版信息

Springer Semin Immunopathol. 2000;22(1-2):45-54. doi: 10.1007/s002810000027.

DOI:10.1007/s002810000027
PMID:10944799
Abstract
摘要

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Activation of skin dendritic cells by immunostimulatory DNA.免疫刺激性DNA对皮肤树突状细胞的激活作用。
Springer Semin Immunopathol. 2000;22(1-2):45-54. doi: 10.1007/s002810000027.
2
Dendritic cells (DC) activated by CpG DNA ex vivo are potent inducers of host resistance to an intracellular pathogen that is independent of IL-12 derived from the immunizing DC.经体外CpG DNA激活的树突状细胞（DC）是宿主对细胞内病原体产生抵抗力的有效诱导剂，这种抵抗力独立于来自免疫DC的IL-12。
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3
Bacterial lipoprotein-based vaccines induce tumor necrosis factor-dependent type 1 protective immunity against Leishmania major.基于细菌脂蛋白的疫苗可诱导针对硕大利什曼原虫的肿瘤坏死因子依赖性1型保护性免疫。
Infect Immun. 2002 Jan;70(1):240-8. doi: 10.1128/IAI.70.1.240-248.2002.
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Vaccination with the Leishmania infantum acidic ribosomal P0 protein plus CpG oligodeoxynucleotides induces protection against cutaneous leishmaniasis in C57BL/6 mice but does not prevent progressive disease in BALB/c mice.用婴儿利什曼原虫酸性核糖体P0蛋白加CpG寡脱氧核苷酸进行疫苗接种可诱导C57BL/6小鼠对皮肤利什曼病产生保护作用，但不能预防BALB/c小鼠的进行性疾病。
Infect Immun. 2005 Sep;73(9):5842-52. doi: 10.1128/IAI.73.9.5842-5852.2005.
5
Genetic immunization with glycoprotein 63 cDNA results in a helper T cell type 1 immune response and protection in a murine model of leishmaniasis.用糖蛋白63 cDNA进行基因免疫可在利什曼病小鼠模型中引发1型辅助性T细胞免疫反应并提供保护。
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The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge.抗原和白细胞介素-12在体内维持Th1记忆细胞中的作用：维持足以介导对感染性寄生虫攻击产生保护作用的记忆/效应Th1细胞需要白细胞介素-12。
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Vaccination with TAT-antigen fusion protein induces protective, CD8(+) T cell-mediated immunity against Leishmania major.TAT-抗原融合蛋白疫苗诱导针对利什曼原虫的保护性、CD8(+) T 细胞介导的免疫应答。
J Invest Dermatol. 2010 Nov;130(11):2602-10. doi: 10.1038/jid.2010.171. Epub 2010 Jun 24.
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The potency and durability of DNA- and protein-based vaccines against Leishmania major evaluated using low-dose, intradermal challenge.使用低剂量皮内攻击法评估基于DNA和蛋白质的针对硕大利什曼原虫疫苗的效力和持久性。
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The immunodominant T helper 2 (Th2) response elicited in BALB/c mice by the Leishmania LiP2a and LiP2b acidic ribosomal proteins cannot be reverted by strong Th1 inducers.利什曼原虫的LiP2a和LiP2b酸性核糖体蛋白在BALB/c小鼠中引发的免疫显性辅助性T细胞2（Th2）反应不能被强Th1诱导剂逆转。
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10
Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: a role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA.含CpG的寡脱氧核苷酸对皮肤树突状细胞的激活：树突状细胞在免疫刺激DNA增强Th1反应中的作用。
J Immunol. 1998 Sep 15;161(6):3042-9.

本文引用的文献

1
Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-gamma-dependent mechanisms.免疫刺激寡脱氧核苷酸通过依赖白细胞介素-12和干扰素-γ的机制促进保护性免疫，并为利什曼病提供全身治疗。
Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6970-5. doi: 10.1073/pnas.96.12.6970.
2
CpG-oligodeoxynucleotides co-stimulate primary T cells in the absence of antigen-presenting cells.在没有抗原呈递细胞的情况下，CpG寡脱氧核苷酸可共刺激原代T细胞。
Eur J Immunol. 1999 Apr;29(4):1209-18. doi: 10.1002/(SICI)1521-4141(199904)29:04<1209::AID-IMMU1209>3.0.CO;2-J.
3
Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: a role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA.
含CpG的寡脱氧核苷酸对皮肤树突状细胞的激活：树突状细胞在免疫刺激DNA增强Th1反应中的作用。
J Immunol. 1998 Sep 15;161(6):3042-9.
4
Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells.细菌DNA和免疫刺激型CpG寡核苷酸可触发小鼠树突状细胞的成熟和激活。
Eur J Immunol. 1998 Jun;28(6):2045-54. doi: 10.1002/(SICI)1521-4141(199806)28:06<2045::AID-IMMU2045>3.0.CO;2-8.
5
Regulation of E-cadherin-mediated adhesion in Langerhans cell-like dendritic cells by inflammatory mediators that mobilize Langerhans cells in vivo.炎症介质对朗格汉斯细胞样树突状细胞中E-钙黏蛋白介导的黏附作用的调节，这些炎症介质在体内可动员朗格汉斯细胞。
J Immunol. 1998 Apr 15;160(8):4067-73.
6
CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis.CpG寡脱氧核苷酸在致死性小鼠利什曼病中引发保护性和治愈性Th1反应。
J Immunol. 1998 Apr 15;160(8):3627-30.
7
CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen.CpG DNA是用重组乙肝表面抗原免疫的小鼠中特异性免疫的有效增强剂。
J Immunol. 1998 Jan 15;160(2):870-6.
8
DNA as an adjuvant: capacity of insect DNA and synthetic oligodeoxynucleotides to augment T cell responses to specific antigen.DNA作为佐剂：昆虫DNA和合成寡脱氧核苷酸增强T细胞对特定抗原反应的能力。
J Exp Med. 1998 Apr 6;187(7):1145-50. doi: 10.1084/jem.187.7.1145.
9
Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization.含有CpG基序的免疫刺激寡脱氧核苷酸在肿瘤抗原免疫中作为免疫佐剂是有效的。
Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10833-7. doi: 10.1073/pnas.94.20.10833.
10
CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity.CpG寡脱氧核苷酸作为开启辅助性T细胞1（Th1）免疫的佐剂。
J Exp Med. 1997 Nov 17;186(10):1623-31. doi: 10.1084/jem.186.10.1623.