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Activation of the innate immune system by CpG oligodeoxynucleotides: immunoprotective activity and safety.

作者信息

Klinman D M, Kamstrup S, Verthelyi D, Gursel I, Ishii K J, Takeshita F, Gursel M

机构信息

Section of Retroviral Research, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.

出版信息

Springer Semin Immunopathol. 2000;22(1-2):173-83. doi: 10.1007/s002810050027.

DOI:10.1007/s002810050027
PMID:10944812
Abstract
摘要

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本文引用的文献

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Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides.CpG寡脱氧核苷酸对哮喘小鼠模型过敏性肺部炎症的长期预防作用
J Immunol. 1999 May 15;162(10):6284-93.
2
CpG-oligodeoxynucleotides co-stimulate primary T cells in the absence of antigen-presenting cells.在没有抗原呈递细胞的情况下，CpG寡脱氧核苷酸可共刺激原代T细胞。
Eur J Immunol. 1999 Apr;29(4):1209-18. doi: 10.1002/(SICI)1521-4141(199904)29:04<1209::AID-IMMU1209>3.0.CO;2-J.
3
Chlamydia infections and heart disease linked through antigenic mimicry.
接种利什曼原虫核小体组蛋白可预防由巴西利什曼原虫引起的新热带皮肤利什曼病。
PLoS One. 2012;7(12):e52296. doi: 10.1371/journal.pone.0052296. Epub 2012 Dec 20.
4
Adjuvants for Leishmania vaccines: from models to clinical application.利什曼病疫苗的佐剂：从模型到临床应用。
Front Immunol. 2012 Jun 11;3:144. doi: 10.3389/fimmu.2012.00144. eCollection 2012.
5
Superior protective immunity against murine listeriosis by combined vaccination with CpG DNA and recombinant Salmonella enterica serovar typhimurium.通过联合接种CpG DNA和重组肠炎沙门氏菌鼠伤寒血清型疫苗对小鼠李斯特菌病产生卓越的保护性免疫。
Infect Immun. 2009 Dec;77(12):5501-8. doi: 10.1128/IAI.00700-09. Epub 2009 Sep 21.
6
Coinjection with CpG-containing immunostimulatory oligodeoxynucleotides reduces the pathogenicity of a live vaccine against cutaneous Leishmaniasis but maintains its potency and durability.与含CpG的免疫刺激寡脱氧核苷酸共注射可降低抗皮肤利什曼病活疫苗的致病性，但保持其效力和持久性。
Infect Immun. 2003 Sep;71(9):5121-9. doi: 10.1128/IAI.71.9.5121-5129.2003.
7
Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profiles.不同的合成核苷酸基序识别模式：具有独特细胞因子诱导谱的强效免疫调节寡脱氧核糖核苷酸制剂的设计与开发。
Nucleic Acids Res. 2003 May 1;31(9):2393-400. doi: 10.1093/nar/gkg343.
8
Use of immunostimulatory sequence-containing oligonucleotides as topical therapy for genital herpes simplex virus type 2 infection.含免疫刺激序列的寡核苷酸作为2型单纯疱疹病毒生殖器感染局部治疗的应用。
J Virol. 2002 Nov;76(22):11387-96. doi: 10.1128/jvi.76.22.11387-11396.2002.
衣原体感染与心脏病通过抗原模拟相联系。
Science. 1999 Feb 26;283(5406):1335-9. doi: 10.1126/science.283.5406.1335.
4
Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria.含有CpG基序的细菌DNA可刺激淋巴细胞介导的小鼠对细胞内细菌致死性感染的保护作用。
J Immunol. 1999 Feb 15;162(4):2291-8.
5
Type I interferon-mediated stimulation of T cells by CpG DNA.CpG DNA介导的I型干扰素对T细胞的刺激作用。
J Exp Med. 1998 Dec 21;188(12):2335-42. doi: 10.1084/jem.188.12.2335.
6
Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: a role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA.含CpG的寡脱氧核苷酸对皮肤树突状细胞的激活：树突状细胞在免疫刺激DNA增强Th1反应中的作用。
J Immunol. 1998 Sep 15;161(6):3042-9.
7
Therapeutic applications of CpG-containing oligodeoxynucleotides.
Antisense Nucleic Acid Drug Dev. 1998 Apr;8(2):181-4. doi: 10.1089/oli.1.1998.8.181.
8
CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis.CpG寡脱氧核苷酸在致死性小鼠利什曼病中引发保护性和治愈性Th1反应。
J Immunol. 1998 Apr 15;160(8):3627-30.
9
Immunostimulatory DNA: sequence-dependent production of potentially harmful or useful cytokines.免疫刺激DNA：潜在有害或有益细胞因子的序列依赖性产生。
Eur J Immunol. 1997 Dec;27(12):3420-6. doi: 10.1002/eji.1830271242.
10
Mitogenicity of DNA from different organisms for murine B cells.不同生物体的DNA对小鼠B细胞的促有丝分裂活性。
J Immunol. 1997 Oct 1;159(7):3119-25.