Liebhart J, Kuś H, Martosz M, Rutowski R, Małolepszy J, Obojski A, Medrala W
Katedry i Kliniki Chorób Wewnetrznych i Alergologii Akademii Medycznej we Wrocławiu.
Pol Merkur Lekarski. 2000 May;8(47):316-8.
Metals are known as a common cause of contact allergies. The prevalence of sensitisation to the composite metals makes for a potential risk of osteosynthesis complications in patients suffering from long bones fractures. In the study the prevalence of delayed allergy to nickel sulphate, potassium dichromate and cobalt was estimated as well as the relation to the osteosynthesis complications. The atopy prevalence was estimated too. Persons under examination were divided into 3 groups. I--treated with osteosynthesis without complications (n = 20), II--treated with osteosynthesis with synostosis complications (n = 16) and III--negative controls (n = 34). We estimated 5% prevalence of delayed allergy to nickel in group I, 6.25% in group II and 5.8% in group III. In patients exposed to chromium we observed delayed allergy prevalence of 5.8% in group I and 3% in group III. No allergy to chromium in group II was revealed. No allergy to cobalt in all groups was revealed. The prevalence of atopy in group II was rare (6.35%) when in group I it was 45% and in controls 32%. The more frequent occurrence of type IV allergy to metals in atopic patients was not confirmed. There was no difference between the prevalence of delayed allergy to metals in groups I and II. Only one case of secondary allergy to chromium was observed.
金属是接触性过敏的常见原因。对复合金属致敏的普遍性使得长骨骨折患者存在骨合成并发症的潜在风险。在该研究中，评估了对硫酸镍、重铬酸钾和钴的迟发性过敏的普遍性以及与骨合成并发症的关系。还评估了特应性的普遍性。受检者被分为3组。I组——接受无并发症的骨合成治疗（n = 20），II组——接受有骨连接并发症的骨合成治疗（n = 16），III组——阴性对照组（n = 34）。我们评估I组中对镍的迟发性过敏患病率为5%，II组为6.25%，III组为5.8%。在接触铬的患者中，我们观察到I组迟发性过敏患病率为5.8%，III组为3%。II组未发现对铬过敏。所有组均未发现对钴过敏。II组特应性的患病率较低（6.35%），而I组为45%，对照组为32%。异位性患者中IV型金属过敏更频繁发生的情况未得到证实。I组和II组对金属迟发性过敏的患病率没有差异。仅观察到1例对铬的继发性过敏病例。
