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[极低热量饮食:它们在肥胖糖尿病患者的治疗中有一席之地吗?]

[Very-low-calorie-diets: is there a place for them in the management of the obese diabetic?].

作者信息

Monnier L, Colette C, Percheron C, Boniface H

机构信息

Service des Maladies Métaboliques, Hôpital Lapeyronie, Montpellier.

出版信息

Diabetes Metab. 2000 Jun;26 Suppl 3:46-51.

Abstract

It is well-recognized that standard caloric restrictions (1500 kcal/day) are usually poorly effective in achieving weight losses in overweight type 2 diabetic patients. For that reason very-low-calorie-diets (VLCDs) were developed as a mean for initiating or accelerating weight reduction. Short-term studies indicate that VLCDs result generally in weight losses that are three times greater than those obtained with standard low-calorie-diets. Fasting blood glucose values are improving in parallel to weight losses and in many patients the improvement in glycemic control is better than that expected from the magnitude of weight losses. However the results are rather disappointing after several months or years of follow-up. For example it has been demonstrated that weight regain can be observed as soon as the patient is shifted to a refeeding or maintenance dietary program at the end of the VLCD period. Long-term results on glycemic control and body weight reduction are generally similar with standard low-calorie-diets and with VLCDs, the final results depending on the magnitude of weight loss whatever the prescribed diet. At short-term the VLCDs can be helpful first for initiating weight losses and second for sensitizing the patient to the potential benefits of complying to dietary measures.

摘要

众所周知,标准热量限制(1500千卡/天)在超重的2型糖尿病患者中通常很难有效实现体重减轻。因此,极低热量饮食(VLCD)被开发出来作为启动或加速体重减轻的一种方法。短期研究表明,VLCD通常导致的体重减轻是标准低热量饮食的三倍。空腹血糖值随着体重减轻而改善,并且在许多患者中,血糖控制的改善比根据体重减轻幅度预期的要好。然而,经过几个月或几年的随访,结果相当令人失望。例如,已经证明,在VLCD期结束时,一旦患者转向重新进食或维持饮食计划,体重就会重新增加。标准低热量饮食和VLCD在血糖控制和体重减轻方面的长期结果通常相似,最终结果取决于体重减轻的幅度,无论规定的饮食如何。短期内,VLCD首先有助于启动体重减轻,其次有助于使患者对遵守饮食措施的潜在益处敏感。

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