Shiono Y, Akiyama K, Hayashi H
Department of Applied Biological Chemistry, College of Agriculture, Osaka Prefecture University, Sakai, Japan.
Biosci Biotechnol Biochem. 2000 Jul;64(7):1519-21. doi: 10.1271/bbb.64.1519.
Four degraded okaramine B (2) products, 4',5'-dihydrookaramine B (3), two azetidine ring-opened compounds (4 and 5) and 1',2',4',5'-tetrahydrookaramine B (6), were prepared and their insecticidal activity was examined. Neither compounds 4 nor 5 showed such activity against silkworms, indicating that the azetidine ring moiety played an important role in the insecticidal activity. Moreover, both compounds 3 and 6 exhibited lower activity than 2, which means that the azocine ring moiety was indispensable to form the active conformation.
制备了四种降解的冈田胺B（2）产物，即4'，5'-二氢冈田胺B（3）、两种氮杂环丁烷开环化合物（4和5）以及1'，2'，4'，5'-四氢冈田胺B（6），并检测了它们的杀虫活性。化合物4和5对家蚕均未表现出这种活性，这表明氮杂环丁烷环部分在杀虫活性中起重要作用。此外，化合物3和6的活性均低于2，这意味着氮杂辛环部分对于形成活性构象是必不可少的。
