Donatsky O
Scand J Dent Res. 1975 Mar;83(2):111-9. doi: 10.1111/j.1600-0722.1975.tb00426.x.
Immunologic cross-reactions between Strep. 2A, fetal human oral mucosa (FHOM), and adult human oral mucosa (AHOM) were investigated by the use of a double layer immunofluorescence staining technique. Rabbit sera were prepared against Strep. 2A and FHOM. Seventeen sera from patients with recurrent aphthous stomatitis (RAS) and with known antibodies against Strep. 2A and AHOM were examined for antibodies against FHOM. The distribution of endpoint titers against FHOM in the sera from RAS differed significantly from the distribution in 17 controls. The immune absorptions in the rabbit sera and in the 17 sera from patients with RAS indicate that some cross-reacting antigenic determinants are shared between Strep. 2A, FHOM, and AHOM. Further, the present results indicate that antibodies are produced against antigenic determinants which are not shared by Strep. 2A, FHOM, and AHOM. The role of cross-reacting antigens in the pathogenesis of RAS is discussed but remains obscure.
采用双层免疫荧光染色技术，研究了2A型链球菌、胎儿人类口腔黏膜（FHOM）和成人人类口腔黏膜（AHOM）之间的免疫交叉反应。制备了抗2A型链球菌和FHOM的兔血清。检测了17例复发性阿弗他口炎（RAS）患者且已知其具有抗2A型链球菌和AHOM抗体的血清中抗FHOM的抗体。RAS患者血清中抗FHOM的终点滴度分布与17名对照者的分布有显著差异。兔血清和17例RAS患者血清中的免疫吸收表明，2A型链球菌、FHOM和AHOM之间存在一些交叉反应性抗原决定簇。此外，目前的结果表明，机体产生了针对2A型链球菌、FHOM和AHOM不共有的抗原决定簇的抗体。文中讨论了交叉反应性抗原在RAS发病机制中的作用，但仍不明确。
