Uher B F, Golden J A
Cell and Molecular Biology Program, University of Pennsylvania School of Medicine and the Children's Hospital of Philadelphia, 19104, USA.
Clin Genet. 2000 Jul;58(1):16-24. doi: 10.1034/j.1399-0004.2000.580103.x.
Disruptions in neuronal migration have been postulated as the basis for many cerebral malformations including lissencephaly, cortical heterotopia, and double cortex. Recently, the genetic basis for some of these disorders has been identified. In this review, we highlight recent advances in our understanding of the molecular mechanisms of neuronal migration and its relationship to cerebral cortical development and neuronal migration disorders. This has allowed us to begin categorizing specific malformations based on their molecular etiology.
神经元迁移紊乱被认为是包括无脑回畸形、皮质异位和双皮质畸形在内的许多脑畸形的基础。最近，已经确定了其中一些疾病的遗传基础。在这篇综述中，我们重点介绍了我们对神经元迁移分子机制及其与大脑皮质发育和神经元迁移障碍关系的最新认识进展。这使我们能够开始根据其分子病因对特定畸形进行分类。
