Blair J M, Hill D A, Bali I M, Fee J P
The Ulster Hospital, Dundonald, Belfast, UK.
Anaesthesia. 2000 Aug;55(8):774-8. doi: 10.1046/j.1365-2044.2000.01470.x.
We studied tracheal intubating conditions in 120 healthy children, aged 3-12 years, in a blinded, randomised clinical trial. Children were randomly allocated to one of three groups: group PS, propofol 3 mg.kg-1 and succinylcholine 1 mg.kg-1 (n = 40); group PA, propofol 3 mg.kg-1 and alfentanil 10 microg.kg-1 (n = 40); group SF, sevoflurane 8% in 60% nitrous oxide in oxygen for 3 min (n = 40). Tracheal intubating conditions were graded according to ease of laryngoscopy, position of vocal cords, coughing, jaw relaxation and movement of limbs. Overall intubating conditions were acceptable in 39 of 40 children in the propofol/succinylcholine group, 21 of 40 children in the propofol/alfentanil group and 35 of 40 children in the sevoflurane group. Children receiving propofol and succinylcholine or sevoflurane had better intubating conditions overall than those given propofol and alfentanil (p < 0.01). In conclusion, anaesthetic induction and tracheal intubation using sevoflurane 8% for 3 min is a satisfactory alternative to propofol with succinylcholine in children.
我们在一项双盲、随机临床试验中，研究了120名3至12岁健康儿童的气管插管情况。儿童被随机分为三组之一：PS组，丙泊酚3mg/kg和琥珀酰胆碱1mg/kg（n = 40）；PA组，丙泊酚3mg/kg和阿芬太尼10μg/kg（n = 40）；SF组，在60%氧化亚氮和氧气中使用8%七氟醚3分钟（n = 40）。根据喉镜检查的难易程度、声带位置、咳嗽、下颌松弛和肢体运动对气管插管情况进行分级。丙泊酚/琥珀酰胆碱组40名儿童中有39名、丙泊酚/阿芬太尼组40名儿童中有21名、七氟醚组40名儿童中有35名的总体插管情况可接受。接受丙泊酚和琥珀酰胆碱或七氟醚的儿童总体插管情况比接受丙泊酚和阿芬太尼的儿童更好（p < 0.01）。总之，对于儿童，使用8%七氟醚进行3分钟的麻醉诱导和气管插管是丙泊酚联合琥珀酰胆碱的一种令人满意的替代方法。
