Spina M, Vaccher E, Nasti G, Tirelli U
Division of Medical Oncology A, National Cancer Institute, Aviano, Italy.
Semin Oncol. 2000 Aug;27(4):480-8.
Hodgkin's disease represents the most common type of non-acquired immunodeficiency virus (AIDS)-defining tumor that occurs in the human immunodeficiency virus (HIV)-positive population. More than 300 cases of Hodgkin's disease in HIV-infected individuals have been reported, mainly from the European countries (ie, Italy, Spain, and France) and to a lesser extent from the United States. All series have documented unusually aggressive tumor behavior, including a higher frequency of unfavorable histologic subtypes, advanced stages, and poorer therapeutic outcome, as compared with the behavior of Hodgkin's disease outside of the HIV setting.
霍奇金淋巴瘤是人类免疫缺陷病毒（HIV）阳性人群中最常见的非获得性免疫缺陷病毒（AIDS）定义性肿瘤。已报道了300多例HIV感染个体患霍奇金淋巴瘤的病例，主要来自欧洲国家（如意大利、西班牙和法国），美国的病例相对较少。与HIV阴性人群中霍奇金淋巴瘤的表现相比，所有系列研究都记录了其异常侵袭性的肿瘤行为，包括不良组织学亚型的发生率更高、分期更晚以及治疗效果更差。
