Schmidt J V, Matteson P G, Jones B K, Guan X J, Tilghman S M
Howard Hughes Medical Institute and Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
Genes Dev. 2000 Aug 15;14(16):1997-2002.
Genes subject to genomic imprinting exist in large chromosomal domains, probably reflecting coordinate regulation of the genes within a cluster. Such regulation has been demonstrated for the H19, Igf2, and Ins2 genes that share a bifunctional imprinting control region. We have identified the Dlk1 gene as a new imprinted gene that is paternally expressed. Furthermore, we show that Dlk1 is tightly linked to the maternally expressed Gtl2 gene. Dlk1 and Gtl2 are coexpressed and respond in a reciprocal manner to loss of DNA methylation. These genes are likely to represent a new example of coordinated imprinting of linked genes.
受到基因组印记影响的基因存在于大的染色体区域中，这可能反映了一个基因簇内各基因的协同调控。对于共享一个双功能印记控制区域的H19、Igf2和Ins2基因，这种调控已得到证实。我们已将Dlk1基因鉴定为一个新的父本表达的印记基因。此外，我们发现Dlk1与母本表达的Gtl2基因紧密连锁。Dlk1和Gtl2共同表达，并且对DNA甲基化缺失以相反的方式做出反应。这些基因可能代表了连锁基因协同印记的一个新例子。
