Moran J V
Department of Human Genetics and Internal Medicine, The University of Michigan Medical School, Ann Arbor 48109-0618, USA.
Genetica. 1999;107(1-3):39-51.
Long Interspersed Nuclear Elements (L1s or LINEs) are the most abundant retrotransposons in the human genome, and they comprise approximately 17% of DNA. L1 retrotransposition can be mutagenic, and deleterious insertions both in the germ-line and in somatic cells have resulted in disease. Recently, an assay was developed to monitor L1 retrotransposition in cultured human cells. This assay, for the first time, now allows for a systematic study of L1 retrotransposition at the molecular level. Here, I will review progress made in L1 biology during the past three years. In general, I will limit the discussion to studies conducted on human L1s. However, interesting parallels to rodent L1s and other non-LTR retrotransposons also will be discussed.
长散在核元件（L1或LINEs）是人类基因组中最丰富的逆转录转座子，约占DNA的17%。L1逆转录转座具有致突变性，其在生殖细胞和体细胞中的有害插入均已导致疾病。最近，一种用于监测培养的人类细胞中L1逆转录转座的检测方法被开发出来。该检测方法首次使得在分子水平上对L1逆转录转座进行系统研究成为可能。在此，我将回顾过去三年中L1生物学领域取得的进展。总体而言，我将把讨论限定在对人类L1进行的研究上。不过，也会讨论与啮齿动物L1及其他非LTR逆转录转座子有趣的相似之处。
