Tarlinton D M, Smith K G
The Walter and Eliza Hall Institute for Medical Research, PO Royal Melbourne Hospital, Victoria 3050, Australia.
Immunol Today. 2000 Sep;21(9):436-41. doi: 10.1016/s0167-5699(00)01687-x.
Until recently, the relationship between apoptosis, selection in the germinal centre (GC) and production of high-affinity antibody-forming cells (AFCs) and memory B cells has been unclear. Here, Tarlinton and Smith present a model that accounts for the switch in GC production from high-affinity AFCs to memory B cells, and explain how Bcl-2, an inhibitor of apoptosis, can influence memory cells but not bone marrow AFCs.
直到最近，细胞凋亡、生发中心（GC）中的选择与高亲和力抗体形成细胞（AFC）及记忆B细胞产生之间的关系仍不明确。在此，塔林顿和史密斯提出了一个模型，该模型解释了生发中心产生从高亲和力AFC向记忆B细胞的转变，并阐述了凋亡抑制剂Bcl-2如何影响记忆细胞而不影响骨髓AFC。
