在拉莫三嗪基础上加用丙戊酸盐：二者药代动力学相互作用的研究
Adding valproate to lamotrigine: a study of their pharmacokinetic interaction.
作者信息
Kanner A M, Frey M
机构信息
Section of Epilepsy and Clinical Neurophysiology, Department of Neurological Sciences, Rush Medical College, and Rush Epilepsy Center, Rush-Presbyterian Saint Luke's Medical Center, Chicago, IL 60612, USA.
出版信息
Neurology. 2000 Aug 22;55(4):588-91. doi: 10.1212/wnl.55.4.588.
The addition of valproic acid (VPA) to a lamotrigine monotherapy regimen (LTG) results in a decrement of LTG clearance. Whether this effect is related to the dose or concentration at steady state (Css) of VPA is yet to be established. This study was conducted to determine whether the dose or Css of VPA were inversely related to LTG clearance in 28 patients with intractable epilepsy who were treated with a combination of LTG and VPA. Correlations between LTG clearance and the dose and Css of VPA and comparisons of LTG clearance during low and high doses of VPA demonstrated that the degree of inhibition of LTG clearance is independent of the dose and Css of VPA.
在拉莫三嗪单药治疗方案（LTG）中添加丙戊酸（VPA）会导致LTG清除率降低。这种效应是否与VPA的剂量或稳态浓度（Css）有关尚待确定。本研究旨在确定在28例接受LTG和VPA联合治疗的难治性癫痫患者中，VPA的剂量或Css是否与LTG清除率呈负相关。LTG清除率与VPA的剂量和Css之间的相关性以及VPA低剂量和高剂量期间LTG清除率的比较表明，LTG清除率的抑制程度与VPA的剂量和Css无关。
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