McConnell M V
Stanford University Medical Center, 300 Pasteur Drive, Room H-2157, Stanford, CA 94305-5233, USA.
Curr Cardiol Rep. 2000 Jul;2(4):300-7. doi: 10.1007/s11886-000-0085-3.
Conventional cardiovascular imaging, with a focus on identifying flow-limiting stenoses, does not directly image the atherosclerotic lesion. Recent clinical and pathobiologic data indicate that stenosis severity does not dictate cardiovascular risk and that there are functional, structural, and biologic features of atherosclerosis that are associated with cardiovascular events. Imaging technologies, such as ultrasound, light, x-ray, magnetic resonance, and targeted contrast agents, have been developed to characterize directly the atherosclerotic vessel wall. They provide promising approaches to predict cardiovascular risk and facilitate further study of the mechanisms of atherosclerosis progression and its response to therapy.
传统的心血管成像主要关注识别血流受限的狭窄病变，而不能直接对动脉粥样硬化病变进行成像。近期的临床和病理生物学数据表明，狭窄严重程度并不能决定心血管风险，动脉粥样硬化的功能、结构和生物学特征与心血管事件相关。已经开发出如超声、光、X射线、磁共振和靶向造影剂等成像技术，以直接表征动脉粥样硬化血管壁。它们为预测心血管风险以及促进对动脉粥样硬化进展机制及其对治疗反应的进一步研究提供了有前景的方法。
