Mareková M, Vávrová J, Vokurková D
Department of Medical Biochemistry, Faculty of Medicine Hradec Králové, Charles University, Prague.
Acta Medica (Hradec Kralove). 2000;43(2):69-73.
TP-53 deficient cells of human leukaemia HL-60 die by massive apoptosis after treatment by high (50-100 nmol/l) doses of DNA damaging agent Idarubicin, regardless of the cell-cycle phase, in which they are affected. In contrary, after relatively low dose 10 nmol/l the cells die after cell-cycle arrest in G2 phase. The results show, that apoptosis induced by idarubicin could appear independently of the cell-cycle phase and that period in which apoptosis is observed is related to the dose of Idarubicin.
人白血病HL-60的TP-53缺陷细胞在受到高剂量（50 - 100 nmol/l）的DNA损伤剂伊达比星处理后，会通过大量凋亡而死亡，无论它们处于受影响的细胞周期阶段如何。相反，在相对低剂量10 nmol/l处理后，细胞在G2期细胞周期停滞之后死亡。结果表明，伊达比星诱导的凋亡可能独立于细胞周期阶段出现，并且观察到凋亡的时期与伊达比星的剂量有关。
