[采用流动注射分析法对滴眼液中羟基苯丙胺进行氧化测定]
[Oxidative determination of hydroxyamphetamine in drops using flow injection analysis].
作者信息
Dolejsová J, Karlícek R, Pospísilová M
机构信息
Katedra analytické chemie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové.
出版信息
Ceska Slov Farm. 2000 Jul;49(4):199-202.
A flow injection-spectrophotometric determination at 540 nm of hydroxyamphetamine is reported. The procedure is based on a coloured reaction with 2-hydrazono-3-methylbenzothiazole (MBTH) and ceric ammonium nitrate (CeIV) as the oxidation reagent. Under optimised conditions, the determination of hydroxyamphetamine is achieved in a range of 0.01-0.2 mmol.l-1 with a relative standard deviation of 0.78% for 0.05 mmol.l-1 (n = 10) and a sample throughput of 75.h-1. The method was used for the determination of medicinal drug in the mass-produced dosage form of Czech origin: Pedrolon drops, Galena a.c.
报道了一种在540nm处流动注射分光光度法测定羟苯丙胺的方法。该方法基于与2-肼基-3-甲基苯并噻唑（MBTH）和硝酸铈铵（CeIV）作为氧化试剂的显色反应。在优化条件下，羟苯丙胺的测定范围为0.01 - 0.2 mmol·l⁻¹，对于0.05 mmol·l⁻¹（n = 10），相对标准偏差为0.78%，进样量为75 h⁻¹。该方法用于测定捷克产大规模生产剂型的药物：Pedrolon滴剂、Galena a.c.
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