Korten J J, Keyser A, Joosten E M, Gabreëls F J
Eur Neurol. 1975;13(2):65-71. doi: 10.1159/000114663.
Fifteen well-documented Parkinson patients treated with Madopar were switched to Sinemet for 3 months. The results were measured with an objective test procedure and compared. The effects of Madopar and Sinemet were equal provided th amount of levodopa was the same. There was one drop-out, because of ventricular extrasystoles. Attention is paid to the occurrence of involuntary hyperkinesias and the on-off-effect.
15名接受美多芭治疗且记录完备的帕金森病患者改用息宁治疗3个月。通过客观测试程序测量并比较结果。若左旋多巴的用量相同，美多芭和息宁的效果相当。有1名患者因室性期前收缩退出研究。研究关注了不自主运动障碍的发生情况以及“开-关”效应。
