Mainou-Fowler T, Dickinson A M, Taylor P R, Mounter P, Jack F, Proctor S J, Nordon J, Middleton P G
University Department of Haematology, School of Clinical Laboratory Sciences, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Leuk Lymphoma. 2000 Aug;38(5-6):547-52. doi: 10.3109/10428190009059274.
Tumour necrosis factor (TNF) alpha is involved in the pathogenesis of established lymphoproliferative disease. Serum levels of TNFalpha and its soluble receptors are above normal values in B-cell chronic lymphocytic leukaemia (B-CLL) and they are valuable prognostic markers in lymphoma patients. The production of TNFalpha is genetically controlled. Altered synthesis of TNFalpha has been associated with polymorphisms at the TNF gene cluster (i.e. TNFA, TNFB and LTB). In the present study, we evaluated the prevalence of the known high TNFalpha- and TNFbeta- producing alleles TNF1, TNF2 of the TNFA gene, TNFB1, TNFB2 alleles of the TNFB gene and of the polymorphic alleles TNFd1, d2, d3, d4 and d5 of the microsatellite TNFd in patients with B-CLL, non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD). This study demonstrates that there is no difference in the frequency of the tested TNF alleles between normal controls and cohorts of patients with lymphoproliferative disease. These results indicate that TNF alleles are not genetic predisposing factors in the development of these diseases.
肿瘤坏死因子（TNF）α参与已确诊的淋巴增殖性疾病的发病机制。在B细胞慢性淋巴细胞白血病（B-CLL）中，血清TNFα水平及其可溶性受体高于正常值，它们是淋巴瘤患者有价值的预后标志物。TNFα的产生受基因控制。TNFα合成的改变与TNF基因簇（即TNFA、TNFB和LTB）的多态性有关。在本研究中，我们评估了TNFA基因已知的高TNFα和TNFβ产生等位基因TNF1、TNF2，TNFB基因的TNFB1、TNFB2等位基因以及微卫星TNFd的多态性等位基因TNFd1、d2、d3、d4和d5在B-CLL、非霍奇金淋巴瘤（NHL）和霍奇金病（HD）患者中的流行情况。本研究表明，正常对照与淋巴增殖性疾病患者队列之间，所检测的TNF等位基因频率没有差异。这些结果表明，TNF等位基因不是这些疾病发生的遗传易患因素。
