斯洛伐克人群中的HLA - A、HLA - B和HLA - C多态性

HLA-A, HLA-B and HLA-C polymorphism in the Slovak population.

作者信息

Kulcsárová E, Buc M, Ferencik S

机构信息

Department of Immunology, School of Medicine, Comenius University, Bratislava, Slovakia.

出版信息

Folia Biol (Praha). 2000;46(4):153-6.

PMID:10954160

Abstract

The occurrence rates of class I HLA alleles were investigated in a sample of the Slovak population by a PCR-SSP method. The frequencies of HLA-A alleles ranged from 0.00 for A4301 to 0.2798 for A0201-22; the frequencies of HLA-B alleles ranged from 0.00 for B 4601,B* 4801-3, B5901,B 7301, and B* 8101 to 0.1101 for B* 4402-10, and those of HLA-C alleles from 0.00 for Cw1301 and Cw 1402-3 to 0.2661 for Cw 0701-10. The occurrence rates of class I HLA alleles established in our study were compared with those in the Czech population. No significant differences were found.

摘要

采用聚合酶链反应-序列特异性引物（PCR-SSP）方法，对斯洛伐克人群样本中的I类HLA等位基因发生率进行了研究。HLA-A等位基因频率范围为：A4301为0.00，A0201-22为0.2798；HLA-B等位基因频率范围为：B 4601、B* 4801-3、B5901、B 7301和B* 8101为0.00，B* 4402-10为0.1101；HLA-C等位基因频率范围为：Cw1301和Cw 1402-3为0.00，Cw 0701-10为0.2661。将本研究中确定的I类HLA等位基因发生率与捷克人群中的发生率进行了比较。未发现显著差异。